Comment on “Renal Protective Effect of Sirtuin 1”

Comment on “Renal Protective Effect of Sirtuin 1”

I read the review article written by Dong et al. [1] regarding the renal effects of sirtuin 1 with great interest. The authors described the harmful effects of advanced glycation endproducts on podocyte apoptosis via increasing Bcl-2 protein secondary to forkhead box O4 (FOXO4) acetylation in diabetes mellitus according toChung et al.’ findings.However, Chuang et al. [2] demonstrated that the a...

Renal Protective Effect of Sirtuin 1

Silent information regulator 2 (Sir2) is a nicotinamide adenine dinucleotide- (NAD(+)-) dependent deacetylase. The homology of SIRT1 and Sir2 has been extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD(+) and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. During the past decade, investigators h...

effect of oral presentation on development of l2 learners grammar

this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...

Topiramate has protective effect on renal injury.

BACKGROUND Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. METHODS A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. A...

Comment on Cisplatin-Induced Renal Impairment